The basic idea of the method to locate genes involved in rare recessive traits is thus to search for regions of homozygosity that are shared by different affected individuals. Young TL, Woods MO, Parfrey PS. Sheffield VC, Stone EM and Carmi R (1998) Use of inbred human populations for identification of disease genes.
Homozygosity Mapping - Encyclopedia of Life Sciences
(1999) Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping. American Journal of Human Genetics 64: 16791685. Annals of Human Genetics 64: 4149. Doctoral Thesis at lUniversité de Paris. American Journal of Human Genetics 70: 920934. Leutenegger AL, Prum B, Genin E. Trends in Genetics 14: 391396.
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